US Coronavirus: vaccination progress made on several fronts, and experts are encouraged

“Overall, things are definitely looking up,” Dr. Paul Offit, director of the vaccine education center at Children’s Hospital in Philadelphia, told CNN on Friday.

• Several mass vaccination sites have been scheduled to open on Friday. New York’s Yankee Stadium began serving eligible residents of the Bronx on Friday morning. Others that are due to open include the San Francisco Moscone Center and two locations in Maryland, including Six Flags America in Bowie. And National Football League commissioner Roger Goodell wrote to Biden, pledging to use each team stadium as a mass vaccination site.
• Next week, pharmacies like CVS, Walgreens, Walmart, Kroger and Publix will offer vaccines in selected stores and states for eligible people. One million doses will be sent to about 6,500 pharmacies in the first phase of a federal program.
• Johnson & Johnson officially applied to the U.S. Food and Drug Administration for an emergency authorization for its Covid-19 single dose vaccine on Thursday. If approved, it would be the third vaccine on the American market, joining the two-dose products of Pfizer / BioNtech and Moderna.
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An FDA advisory committee will meet on the request on February 26. The panel will make a recommendation that the FDA will consider when making an authorization decision.

Johnson & Johnson reported what appears to be a lower efficacy than the other two vaccines in preventing moderate disease. But the company emphasized that its candidate was tested when certain strains of the virus were more prevalent – and that it was still 85% effective against serious illnesses.

And experts pointed out the potential advantages: unlike the Pfizer and Moderna vaccines, Johnson & Johnson would give just one injection; it does not need to be stored in freezers; and can be stored for three months at refrigerator temperature.

The addition of a new vaccine will increase the supply and allow more people to be inoculated more quickly, said Offit and other experts.

And “the weather will get warmer and when it does, it will be less easy for this virus to be transmitted,” said Offit.

“I really think we will get over it in the summer or late summer, because I think everything is now going in the right direction,” said Offit.

Dr Ashish Jha, dean of Brown University’s school of public health, also said on Friday that the vaccination situation in the United States “is improving.”

“We are doing about 1.3 million (shots) a day (and) it was harmed a little by the snowstorm,” said Jha. “We can reach 2 (millions a day), or even better than that.”
Dr. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, warned that more contagious variants of the coronavirus may still generate significant outbreaks of infections in the coming weeks, and that vaccines alone may not prevent this. .

New York to offer vaccines to people with underlying diseases

New York may be the first state to offer access to the vaccine to people with a comorbidity or simultaneous presence of two or more medical conditions, regardless of their age.

“New Yorkers with underlying comorbidities and conditions exist in the entire population of the state – they are our teachers, lawyers and carpenters, in addition to the doctors who keep us safe every day, and are a highly affected population,” said Governor Andrew Cuomo. “We are committed to vaccinating the vulnerable populations that have suffered the most, as we distribute a strictly limited supply of vaccines, and people with comorbidities account for 94 percent of the state’s COVID deaths.”

The governor’s office listed cancer, chronic kidney disease, lung disease and heart problems as some of the underlying comorbidities and conditions that the state will use to determine eligibility for the Covid-19 vaccine.

Starting on February 15, doses reserved for hospital staff will be relocated to those with comorbidities if hospital staff have not used them, Cuomo said on Friday.

Approximately 75% of hospital staff have been vaccinated, and those who have not done so will still have to get their vaccines before access is open to others.

Health departments will work with the state and the CDC to determine which medical conditions qualify.

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People line up for vaccines at New York's Yankee Stadium on Friday, the day the mass vaccination site opened up for residents of the Bronx.

The model predicts a steady drop in the mortality rate – unless variants intervene

The speed with which the variants spread versus the speed of vaccinations will be a key factor in the number of coronavirus deaths in the coming months, according to a forecast by the University of Washington Institute of Health Metrics and Assessment.

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Currently, the IHME projects that the number of Covid-19 deaths in the country per day will drop steadily until June 1, in part because of the launch of vaccines and surveys that show growing percentages of Americans saying they are willing to get vaccines.

The United States averaged more than 3,230 Covid-19 deaths per day last week, not far from the record average of 3,357 set on January 13, according to Johns Hopkins University.

The IHME says that the most likely scenario projected would have deaths per day dropping to just under 2,000 on March 1; to 1,486 on April 1; to 1,245 on May 1; and 628 on June 1.

But in the worst case, including the spread of the rampant variant, daily death rates could rise again in March – and even exceed 2,600 a day in mid-April before falling, says the IHME.

“If variants are more widespread and people return to their previous lives faster” after being vaccinated, “then you approach our worst scenario we launched,” said IHME director Dr. Chris Murray, Anderson Cooper of CNN on Friday night.

The Centers for Disease Control and Prevention said variant B.1.1.7 could be the dominant strain in the United States in March. The UK variant is already on track to become dominant in hotspots like Florida and southern California “in a few weeks”, according to a testing company called Helix, which helped to identify most cases in the United States .
At least 618 cases of variants that are believed to be more transmissible have been identified in 33 states, according to the CDC. The vast majority of these – 611 – are the variants identified for the first time in the United Kingdom (B.1.1.7), with some others being the first ones identified in South Africa (B.1.351) and Brazil (P.1).
At least one case, that of a man who has been chronically infected for months, indicates that the variants not only come from abroad, but can be grown at home in American patients.

Genetic tests showed that the patient, who had an underlying disease that weakened his immunity, had been infected with the same virus all the time, but that he was evolving as he reproduced.

“It was incredible,” said Dr. Jonathan Li, who heads a laboratory at Brigham and Women’s Hospital in Boston that studies viruses and their mutations and was called in to help study the patient’s case.

For now, cases of Covid-19 and hospitalizations in the United States have been decreasing after a sudden increase in the holiday era.

The country averaged about 130,402 new Covid-19 cases per day last week – down more than 47% from a peak average of more than 249,000 per day on January 8, according to data from Johns Hopkins.

The number of people in US hospitals on Thursday was 88,688 – the lowest since November 24.

CDC Director: Guidance on reopening schools will be launched next week

The CDC will issue guidance on reopening schools next week, said CDC director Dr. Rochelle Walensky, during a meeting at the White House on Friday.
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During the briefing, CNN asked whether one of Walensky’s previous comments about schools – that with the distance, masking and proper testing, schools could safely resume face-to-face classes even before all teachers were vaccinated – was the official guidance of the CDC.

“Our goal is to get the kids back to school,” said Walensky on Friday. “Schools must be the last places closed and the first open. Our goal is to ensure that when children return to schools, we do this with the safety of children and teachers ”.

“One of the things we need to do to ensure that schools are safe is to ensure that the spread of the disease in the community decreases,” said Walensky. “We are actively working on the guidance, the official guidance, which will be released next week.”

So far, 24 states and Washington, DC, are explicitly allowing some teachers or school staff to receive the vaccine.

The Biden administration plans to make 60 million tests available at home this summer

The Biden government announced on Friday that, under the Defense Production Act, some 60 million Covid-19 home tests will be available to the public by the end of this summer.

These tests will be in addition to Ellume’s home tests that the government previously announced, said Tim Manning, Covid-19’s supply coordinator, during a press conference at the White House.

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“The country is right behind where we need to be in testing,” said Manning.

“In the coming weeks, the United States government has plans to invest in six other suppliers to rapidly increase testing capacity,” said Manning.

On Monday, Andy Slavitt, the senior White House Biden consultant to Covid’s response, said during a meeting at the White House that the Department of Defense and the U.S. Department of Health and Human Services are working with the Australian company. Ellume to provide more of your mindfulness. Covid-19 conducts domestic testing to the United States and ships 100,000 test kits per month to the United States from February to July.

Now, “having another 60 million home tests available during the summer is exactly what the country needs,” said Slavitt during Friday’s briefing.

CNN’s Michael Nedelman, Maggie Fox, Andrea Diaz, Jacqueline Howard, Sara Murray, Naomi Thomas, Kristina Sgueglia and Theresa Waldrop contributed to this report.

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