Healthy vegetable-based diet linked to good microbes in the gut: study

Intestinal microbiologists had an idea of ​​how diet affects the intestinal microbiome, but not much data to provide evidence that there is a relationship. In an article published Monday in Nature Medicine, a collaboration of intestinal microbiome researchers at various institutions provides the first batch of evidence linking the diet to the intestinal microbiome.

The study’s authors included researchers from King’s College London, Harvard TH Chan School of Public Health, Massachusetts General Hospital (MGH), University of Trento, Italy, and health science startup ZOE Global. The study, called PREDICT 1, involved more than 1,000 people in the UK and 100 in the United States

Participants in the PREDICT 1 study had their intestinal microbiomes sequenced by the study authors. They also provided detailed information on the long-term diet and blood samples. The researchers found that there were significant associations between microbes and nutrients and types of food. The authors suggest that the quality of the food (unprocessed vs. highly processed), the source of the food (vegetable vs. animal) and the type of food (healthy vs. unhealthy) were important to the overall health and ecology of the microbiome .

In particular, the study results suggest that the diversity of healthy plant-based foods in the diet “shapes the composition of the intestinal microbiome,” according to the article. Another interesting finding is that there may be microbial obesity indicators that researchers can identify in each individual. The researchers were able to identify metabolites in the blood that can serve as biomarkers that indicate risk of cardiovascular disease.

“We were surprised to see groups so large and clear of what we informally call ‘good’ and ‘bad’ microbes emerging from our analysis,” says Nicola Segata, who is a professor and principal investigator at the Computational Metagenomics Laboratory at the University of Trento, Italy , and leader of the microbiome analysis in the study, according to a press release.


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The study results suggest that we may be able to affect microbes that can survive in our intestines based on our diets. Tim Spector, who is an epidemiologist at King’s College London, scientific founder of ZOE, the company that funded and supported the study, and started the PREDICT study program, says: “When you eat, you’re not just feeding your body, you’re feeding the trillions of microbes that live inside your gut. ”

The company plans to bring this science to the public.

“Through ZOE, we can now offer the opportunity to find out which of these microbes they live in their intestines,” says Spector in the press release. “Using machine learning, we can share with you our calculations of how your body will respond to any food.”


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The next step in the research is to start clinical trials to test whether people can change the composition of their gut microbiome by changing their diet, with luck to increase the good microbes over the bad ones, according to The New York Times.

“We think there are many small changes that people can make and that can have a big impact on their health, which can be mediated by the microbiome,” said Sarah Berry, nutrition scientist at King’s College London and co-author of the study. for the New York Times.

The next phases of the study, PREDICT 2, completed data collection in 2020 as a collaboration of ZOE with Massachusetts General Hospital and Stanford University. The main objectives of this study are to better understand the response to food intake, including meals and times of the day, according to Fiana Tulip, head of communication at ZOE. PREDICT 3 was launched a few months ago, according to the press release. Its aim is to validate and “understand the effects of ZOE dietary advice on weight, health and well-being markers,” said Tulip in an email to Changing America.


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