Sniffer dogs from Covid-19: what does science say?

While the AmericanAirlines Arena in Miami reopens to a limited number of fans on Thursday, the Miami Heat is bringing dogs being billed as “coronavirus detection dogs” to track guests and staff as they arrive at the facility. The team will be the first in the NBA to use canines to screen the public.

The science is still unclear whether dogs can, in fact, detect coronavirus infection in people. The team has been experimenting with dogs on a smaller scale to select personnel – and “we’ve learned a lot during that time,” Matthew Jafarian, executive vice president of business strategy at Miami Heat, told CNN.

If the dog sits next to you, says the Miami Heat, it signals the handler that it may have detected the Covid-19. A team member will assist you and your group with reimbursement and provide additional health and safety information – but you and your group will not be allowed to enter the arena.

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Jafarian said the Miami Heat sees detection dogs as just a tool in a much larger arsenal of Covid-19 security measures – which also includes a health screening questionnaire, mandatory mask policy, cashless concession booths. , not allowing food and drinks in the arena bowl and physical distance, among other tools.

Canine experts emphasize that while research on dogs for coronavirus looks promising, it is not yet definitive. Studies exploring the reliability of dogs in detecting an active coronavirus infection are still ongoing – and there are many questions to be answered.

“I think it’s so new and innovative that we still have to determine how effective and how reliable canines are in detecting this type of thing,” said Dr. Douglas Kratt, president of the American Veterinary Medical Association.

“We are very much ahead of that,” he said. “But it is very exciting to see that we could have another tool to detect the coronavirus.”

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At the start of the pandemic, the Miami Heat first explored detection dogs – along with other approaches – to track the new coronavirus on its premises.

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“During the NBA bubble it was really when we started to seriously research how we could safely bring fans back into the arena,” said Jafarian, referring to the strict blocking that NBA players and teams suffered last year as the “bubble”.

“We looked at a variety of options. There were breathalyzer tests that we looked at. We looked at traditional diagnostic tests, such as rapid antigen and PCR tests. And we thought operationally how we could manage that to hundreds and thousands of people arriving at the building.”

Jafarian added that, around the same time, some initial studies were being published in Europe and elsewhere. The studies have not been proven and have been published as pilot and proof of concept documents. When asked if the research was not definitive, Jafarian replied that he was originally skeptical, but found the studies “convincing” because they achieved similar results. He said the Miami Heat is taking its canine program “very slowly” until it learns more.

In July, researchers in Germany published a pilot study in the journal BMC Infectious Diseases describing how they trained eight dogs to discriminate between saliva samples from someone sick with Covid-19 and a healthy person.

The researchers reported in their study that among 1,012 samples, the dogs correctly identified 157 positive samples and 792 negative samples, but incorrectly identified 33 samples as negative and 30 samples as positive. The dogs “achieved an overall average detection rate of 94%,” the researchers wrote.

In December, a separate research team from France and Lebanon published a proof-of-concept study in PLOS ONE magazine detailing how they trained six dogs to tell the difference between armpit sweat from someone who has Covid-19 and someone who doesn’t . Some of the dogs had a 76% success rate, while others had a 100% success rate in that study.

But these studies were conducted in controlled environments and there was some repeated use of samples – so you cannot rule out whether a dog was memorizing the odor of a sample. Further research is needed to determine whether similar discoveries could emerge in the real world and among a larger group of detection dogs.

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Elsewhere, in the UK, a team from the London School of Hygiene & Tropical Medicine has been training six dogs in the hope that they will be able to detect Covid-positive people – even if people do not show symptoms.
In Finland, a group of dogs trained to detect Covid-19 started work at Helsinki airport in September in an effort to identify people who contracted the virus. And in Chile, police dogs are being trained to sniff out Covid-19 infections.

“We saw what the airport in Finland was doing, and then an airport in Dubai, and [governments] in Mexico and Chile, “said Miami Heat’s Jafarian.

Then, a few months later, a new company called SNIFF approached the Miami Heat with the offer to use detection dogs as a coronavirus screening tool in the team’s arena.

Jafarian said, “we decided to take a step forward.”

‘The virus is new’, using detection dogs is not

Aron Shteierman, SNIFF’s executive director, told CNN that he had no experience in dog training, but when the coronavirus pandemic started, he saw canines as a possible rapid, non-invasive screening tool.

In the spring of last year, Shteierman turned his idea into a business: SNIFF. Then he said he contacted the Global K9 Protection Group and asked for a partnership, specifically to use and train the company’s dogs for coronavirus detection. Global K9 Protection Group agreed.

“The virus is new, but the application of using a detection dog to track people is not,” Michael Larkin, vice president of commercial services for the Global K9 Protection Group, told CNN.

SNIFF and Global K9 Protection Group then contacted Miami Heat.

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Shteierman confirmed that “we do not use live viruses to train canines”, but he did not share specific details about the dog training process with CNN. He said it was “proprietary” information.

CNN was unable to examine the company’s research behind detection dogs, as well as the effectiveness of dogs, because it has not yet been published. For this research, Shteierman said, “We took the canines to a test site where the PCR test was being carried out and made comparison results.”

However, dogs are no substitute for getting an actual diagnosis from a PCR test or medical professional, said Larkin of the Global K9 Protection Group.

“It is important for people to understand that this technology and solution is evolving and is not a substitute for going to the doctor or a PCR test,” Larkin told CNN. “The dog was designed to be an initial screening tool for the human body, but if there was a positive indication, our first recommendation would be to seek professional medical care and do a PCR test.”

‘Some level of evidence, but I don’t think it’s rigid’

There are still significant issues.

For example, some studies suggest that a dog handler’s prejudice may influence a detection dog’s behavior. A 2011 study published in the journal Animal Cognition found that, among 18 teams of handlers and dogs, a dog was more likely to erroneously “alert” that it had detected a smell – so give a false positive – when the handler believed it was a perfume gift.
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And when it comes to coronavirus specifically, it is unclear what exactly dogs may be getting when they are trained to detect Covid-19.

In the two previous studies from Germany, France and Lebanon – published in the magazines BMC Infectious Diseases and Plos One – both research teams suggested that their dogs could be detecting the “volatile organic compounds” that are produced during coronavirus infections.

“It’s not like the coronavirus has a smell. It is when a person is infected with a virus, their metabolism changes in such a way, their breathing changes in such a way that there are subtle changes that you can train dogs to detect. it’s not the virus they’re detecting, it’s the physiological changes induced by the virus they’re detecting, “said Dr. Amesh Adalja, senior scholar at the Johns Hopkins University Health Security Center, who was not involved in the studies.
“That’s probably what dogs are reacting to,” he said. “We know that, for other purposes, we use dogs that way to sniff out bombs, for drugs, and they tried to use them in diagnosing cancer. They have been trying to use them also for diagnosing C. diff”, which is the bacterium Clostridioides difficile, which causes severe diarrhea and inflammation of the colon.
A 2018 study suggests that a 3-year-old German shepherd named Piper and a 3-year-old Border Collie named Chase were able to detect the presence of C. difficile in stool samples that were stored in a refrigerator with a sensitivity ranging from 77.6 to 92.6 and a specificity of 84.4 to 85.1.
However, C. diff is a bacterium. There is not much research on dogs that detect viral infections. A study, published in the journal Frontiers in Veterinary Science in 2015, found that two trained dogs could discern between cultured cells infected with three different viruses – but they were viruses that infect cattle, not humans.

Adalja said more research on dogs is needed to detect coronavirus.

“There is beginning to be some level of evidence, but I don’t think it’s ironclad,” said Adalja. “It is not definitive yet.”

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